Association of sVCAM1 with interleukin -6 among rheumatoid arthritis patients

DOI:

https://doi.org/10.36371/port.2025.1.1

Authors

  • Shahad F. Obeid Department of Chemistry, College of Sciences, University of Baghdad, Baghdad, Iraq.
  • Wasnaa Jomaa Mohammed Department of Basic Sciences, College of Nursing, University of Baghdad, Baghdad, Iraq.
  • Noor Alhuda Kh Ibrahim Department of Basic Sciences, College of Nursing, University of Baghdad, Baghdad, Iraq.

Symmetric synovitis is a histological characteristic of Rheumatoid Arthritis (RA), a systemic inflammatory connective tissue disease. An accelerated atherosclerosis process is the primary mechanism by which RA increases cardiovascular morbidity and mortality. The subject of the study consisted of two groups, the first group included 40 patients, all over the age of 18, with 35 females and 5 men participating also second group included 40 healthy controls who did not have any autoimmune disorders. The biochemical analyzer konelab prime 30ISE (bioMérieux france, craponne, france) was used to measure C-reactive protein and other parameters. The levels of inflammatory and immunological parameters, such as ESR, RF, CRP, and ACPA, were importantly higher in RA patients (52.37 ± 10.41, 44.28 ± 14.75, 57.00 ± 17.67, and 45.17 ± 12.3), respectively (p< 0.001). IL-10 pg/ml, IL-6 pg/ml, TNF-α pg/ml, and sVCAM ng/ml in RA patients (21.70 ± 3.08,54.42 ± 5.36,40.69 ± 7.26 and 7.12 ± 0.81) respectively (p< 0.001). The Logistic regression model shows that immunological parameters such as sVCAM correlate directly with IL-10 among RA patients. This result might refer to the fact that the RA condition enhances the production of sVCAM about IL-10. Also, it showed that the sVCAM directly correlates with IL-6 among RA patients. RA patients showed an association of sVCAM-1 directly correlated with IL-6. This result might refer to the fact that the RA condition enhances the production of sVCAM about IL-6.

Keywords:

Rheumatoid Arthritis, Cardiovascular Morbidity, Inflammatory Parameters, sVCAM, IL-6

[1] Khir NAM, Noh ASM, Long I, Ismail NI, Siran R, Ismail CAN. Inflammatory-associated apoptotic markers: Are they the culprit for rheumatoid arthritis pain? Mol Biol Rep. 2022 Oct;49(10):10077-10090. doi: 10.1007/s11033-022-07591-y. Epub 2022 Jun 14. PMID: 35699858 Review.

[2] Mohammad WJ, Kh. Ibrahim NA, Obed SF, Obed SF, Sh. Jebur M. Association of TNFRII polymorphisms and IL-37 in rheumatoid arthritis Iraqi patients. J.port.sci.res [Internet]. 2021;4(1):30–5. Available from: http://dx.doi.org/10.36371/port.2021.1.7.

[3] Bernatova I., Andriantsitohaina R., Arribas S.M., Matchkov V.V. Endothelium in diseased states. Biomed. Res. Int. 2014;2014:810436. Doi: 10.1155/2014/810436. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

[4] Monnier A., Prigent-Tessier A., Quirié A., Bertrand N., Savary S., Gondcaille C., Garnier P., Demougeot C., Marie C. Brain-derived neurotrophic factor of the cerebral microvasculature: A forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain. Acta Physiol. (Oxford) 2017;219:790–802. doi: 10.1111/apha.12743.

[5] Mohammad WJ, Ibrahim NA, Obeid SF. Decreased expression of IL-4 Gene and Exploring of mutable lymphotoxin alpha (TNF-β) gene in Patients with Systemic Lupus Erythematosus. J.port.sci.res [Internet]. 2024;7(1):6–14. Available from: http://dx.doi.org/10.36371/port.2024.1.2

[6] Zhang H., Park Y., Wu J., Chen X.P., Lee S., Yang J., Dellsperger K.C., Zhang C. Role of TNF-alpha in vascular dysfunction. Clin. Sci. 2009;116:219–230. doi:10.1042/CS20080196.

[7] Tanasescu C., Jurcut C., Jurcut R., Ginghina C. Vascular disease in rheumatoid arthritis: From subclinical lesions to cardiovascular risk. Eur. J. Intern. Med. 2009;20:348–354. doi: 10.1016/j.ejim.2008.09.005.

[8] Al-azzawi NN, Hussein MK, Khalaf MI. Verifying The Association Between IL6 -174G/C Polymorphism in Type 2 Diabetes Mellitus. J.port.sci.res [Internet]. 2024;7(1):36–42. Available from: http://dx.doi.org/10.36371/port.2024.1.6

[9] Lopez-Vilchez I, Diaz-Ricart M, Navarro V, Torramade S, Zamorano-Leon J, Lopez-Farre A, et al.. Endothelial damage in significant depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model. Transl Psychiatry 2016; 6: e886

[10] Schlesinger M, Bendas G.. Vascular cell adhesion molecule-1 (VCAM-1)-An increasing insight into its role in tumorigenicity and metastasis. Int J Cancer 2015; 136: 2504–2514.

[11] Cook-Mills JM, Marchese ME, Abdala-Valencia H.. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal 2011; 15: 1607–1638.

[12] Hansildaar R., Vedder D., Baniaamam M., Tausche A.K., Gerritsen M., Nurmohamed M.T. Cardiovascular Risk in Inflammatory Arthritis: Rheumatoid Arthritis and Gout. Lancet Rheumatol. 2021;3:e58–e70. doi: 10.1016/S2665-9913(20)30221-6

[13] Lacy M., Bürger C., Shami A., Ahmadsei M., Winkels H., Nitz K., van Tiel C.M., Seijkens T.T.P., Kusters P.J.H., Karshovka E., et al. Cell-Specific and Divergent Roles of the CD40L-CD40 Axis in Atherosclerotic Vascular Disease. Nat. Commun. 2021;12:3754. doi: 10.1038/s41467-021-23909-z

[14] Pereira-Da-silva T., Napoleão P., Pinheiro T., Selas M., Silva F., Ferreira R.C., Carmo M.M. The Proinflammatory Soluble CD40 Ligand Is Associated with the Systemic Extent of Stable Atherosclerosis. Medicina. 2021;57:39. doi: 10.3390/medicina57010039

[15] ödergren A., Karp K., Bengtsson C., Möller B., Rantapää-Dahlqvist S., Wållberg-Jonsson S. Biomarkers Associated with Cardiovascular Disease in Patients with Early Rheumatoid Arthritis. PLoS ONE. 2019;14:e0220531. doi: 10.1371/journal.pone.0220531.

[16] Román-Fernández I.V., García-Chagollán M., Cerpa-Cruz S., Jave-Suárez L.F., Palafox-Sánchez C.A., García-Arellano S., Sánchez-Zuno G.A., Muñoz-Valle J.F. Assessment of CD40 and CD40L Expression in Rheumatoid Arthritis Patients, Association with Clinical Features and DAS28. Clin. Exp. Med. 2019;19:427–437. doi: 10.1007/s10238-019-00568-5

[17] Makki J, Al Khafaj AH. Endometrial biopsy is an important diagnostic tool for the evaluation of abnormal uterine bleeding. J.port.sci.res [Internet]. 2021;4(1):19–22. Available from: http://dx.doi.org/10.36371/port.2021.5

[18] Varona J.F., Ortiz-Regalón R., Sánchez-Vera I., López-Melgar B., García-Durango C., Castellano Vázquez J.M., Solís J., Fernández-Friera L., Vidal-Vanaclocha F. Soluble ICAM 1 and VCAM 1 Blood Levels Alert on Subclinical Atherosclerosis in Non Smokers with Asymptomatic Metabolic Syndrome. Arch. Med. Res. 2019;50:20–28. doi: 10.1016/j.arcmed.2019.05.003

[19] Videm V., Albrigtsen M. Soluble ICAM-1 and VCAM-1 as Markers of Endothelial Activation. Scand. J. Immunol. 2008;67:523–531. doi: 10.1111/j.1365-3083.2008.02029.x

[20] Hashim RM, Farid YYZ. Design, synthesis, in silico study and anti-inflammatory evaluation of new ketoprofen thiourea derivatives. J.port.sci.res [Internet]. 2024;7(1):69–76. Available from: http://dx.doi.org/10.36371/port.2024.1.9

[21] Davies R, Williams J, Sime K, Jin HS, Thompson C, Jordan L, Lang D, Halcox JP, Ellins E, Jones GW, Jones SA, Rose-John S, Williams A, Choy E. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology (Oxford). 2021 Jun 18;60(6):2852-2861. doi: 10.1093/rheumatology/keaa725. PMID: 33313793 Free PMC article.

[22] Foster W, Carruthers D, Lip GY, Blann AD. Inflammatory cytokines, endothelial markers, and adhesion molecules in rheumatoid arthritis: effect of intensive anti-inflammatory treatment. J Thromb Thrombolysis. 2010 May;29(4):437-42. doi: 10.1007/s11239-009-0370-y. PMID: 19578810 Clinical Trial.

Obeid, S. F. ., Mohammed, W. J. ., & Ibrahim, N. A. K. . (2025). Association of sVCAM1 with interleukin -6 among rheumatoid arthritis patients. Journal Port Science Research, 8(1), 1–7. https://doi.org/10.36371/port.2025.1.1

License

Copyright (c) 2025 Journal Port Science Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Downloads

Download data is not yet available.