Evaluation of some immunological and physiological parameters in patients with chronic kidney disease infected with Toxoplasma gondii

DOI:

https://doi.org/10.36371/port.2025.1.7

Authors

  • S. M. Marhoon Biology Department, Collage of Science, Uruk University, Najaf, Iraq.
  • S. SH. Hamad Biology Department , Collage of Science, Kirkuk University, Altameer, Iraq.

Abstract Background - Chronic kidney disease (CKD) is defined as a decrease in glomerular filtration rate, increased urinary albumin excretion, and, ultimately, complete loss of kidney function or kidney damage. Toxoplasma gondii is a protozoan parasite responsible for toxoplasmosis a significant disease that affects over a billion people worldwide in humans, toxoplasmosis spreads through two primary routes: horizontal transmission, which occurs through accidental ingestion of Toxoplasma gondii oocysts present in contaminated food or water and vertical transmission where the infection is passed from mother to baby via the placenta.  The aim of the current study was to detect the effect of toxoplasmosis on kidney function and determining some immunological and physiological parameters in immunosuppressed patients (kidney failure patients) compared to healthy people Methods The study involved the analysis of 90 blood samples, comprising 80 samples from patients diagnosed with Chronic Kidney Disease (CKD) and 10 samples from healthy individuals who served as control subjects   Results   Results revealed  decrease in the level of both CD4+ and CD8+ in infected CKD compared with the control group, The CD4+/CD8+ concentration ratio was increased in  infected CKD As for biochemical tests, the results showed an increase in the concentration of urea, creatinine, phosphorus, and the liver enzyme ALT, and no significant differences were recorded in the concentration of the liver enzyme AST and Alk.phosphatase  Conclusions: The study revealed a decrease in immunological parameters and an increase in physiological parameters in kidney failure patients .                                                                                                                                                                                                                                                                                                   

Keywords:

Toxoplasma gondi, CKD chronic kidney disease, CD4 , CD8 , biochemical test

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Marhoon , S. M. ., & Hamad, S. S. . (2025). Evaluation of some immunological and physiological parameters in patients with chronic kidney disease infected with Toxoplasma gondii. Journal Port Science Research, 8(1), .36–40. https://doi.org/10.36371/port.2025.1.7

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