A Review article: Topical Drug Delivery System (Skin)

المؤلفون

  • Hiba Mohammed Suza Suza College of pharmacy, Uruk University, Baghdad, Iraq.
  • Balkis Ahmed Kamal College of pharmacy, Osol Aldeen University, Baghdad, Iraq
  • Nadeem Abdalsatar Abdalrazaq College of pharmacy, Uruk University, Baghdad, Iraq.
  • Asmaa M Rashid College of pharmacy, Uruk University, Baghdad, Iraq.
  • Haifa T. Abu Tbeekh College of pharmacy, Uruk University, Baghdad, Iraq.
  • Reem G Hussein College of pharmacy, Uruk University, Baghdad, Iraq.
  • Hawraa K Khafeef College of pharmacy, Uruk University, Baghdad, Iraq.

In general; many approaches found to delivered the drug to the site of action, one of these approaches used the skin barrier as a rout to reach the drug to the local or systemic targeting; Both local and transdermal drug product are intended for external use (applied on the skin). It was localized action on one or more layers of the skin, or may reach to the systemic circulation to get systemic effect. So, in this review authors aimed to highlight on the anatomy of the skin layers epidermis, dermis and hypodermis (to know the way of the drug transport), drug application, drug penetration through the skin, factors affecting on the skin drug absorption, advantage of this rout and limitation of the drug delivery system; in addition to mention to many examples of this dosage forms are used in drug delivery system. Finally, this approach of drug delivery system is widely used and preferred from the patient at any life stages because of its improved the patient compliance and decreased the side effects of drugs in addition to easy rout of admiration and avoid pain and suitable to patient with swallowed problem.

الكلمات المفتاحية:

Topical drug delivery system، localized therapeutics، transdermal، skin، layers، compliance

[1] Raina N and etal. New insights in topical drug delivery for skin disorder: from a nanotechnological perspective. Acs omega. 2023; 8:19145- 19167.

[2] Water K S, Roberts M S. The structure and function of skin in dermatology and transdermal formulation. Marcel dekker. 2002; 1- 39.

[3] Yu Y et al. enhancing permeation of drug molecules across the skin via delivery in nanocarriers: novel strategies for effective transdermal applications. Front. Bioeng. Biotechnol. 2021; 9: 1- 17.

[4] Kolimi P, Narala S. Nyavanandi D, Youssef A A and Dudhipala N. Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements. Cells. 2022;11: 2439 https://doi.org/10.3390/cells11152439Academic

[5] Joung W Y et al. Recent advances in transdermal drug delivery systems: a review. Biomaterials Research. 2021; 25:24. https://doi.org/10.1186/s40824-021-00226-6

[6] Zeb A et al. potential of nanoparticulate carriers for improved drug delivery via skin. Journal of pharmaceutical investigation. 2019; 49: 485- 517. https://doi.org/10.1007/s40005-018-00418-8

[7] Shargel L, Sunsanna Wu-pong and Rew B.C YU. Applied biopharmaceutics & pharmacokinetics. 2022, Five edition, Ch. 1; page: 38.

[8] Keleb E, Sharma R K, Bmosa E. Transdermal drug delivery system design and evaluation. Int J Adv pharm Sci. 2010; 1: 201- 211.

[9] Eliana S et al. Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery. Heliyon. 2022; 8: 2- 16.

[10] Peppas N A. hydrogel in pharmaceutical formulation. European journal of pharmacology & biopharmaceutical. 2000; (50): 27- 28.

[11] Rodrigues V et al. Delivery of drugs applied topically to the skin. Expert Rev. Dermatol. 2012; 7(4): 383–397.

[12] Choi E. Topical agents: a thoughtful choice for multimodal analgesia. Korean J Anesthesiol. 2020;73(5):384-393. https://doi.org/10.4097/kja.20357

[13] Vyas S P and Khar R K. controlled drug delivery concepts and advances: transdermal drug delivery. 2002; Chapter 10. p: 411- 476.

[14] Raina N et al. New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective. ACS Omega.2023; 8: 19145−19167. http://pubs.acs.org/journal/acsodf?ref=pdf

[15] Benson H A et al. Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies. Current Drug Delivery, 2019, 16, 444-460.

[16] Garg T, Rath G and Goyal A K. Comprehensive review on additives of topical dosage forms for drug delivery. Informa healthcare. 2015; 22(8) 969- 987.

[17] Jassim B M, Al-Khedairy E B. Formulation and in vitro /in vivo evaluation of silymarin solid dispersion based topical gel for wound healing. Iraqi J Pharm Sci. 2023; 32: 42- 53. https://doi.org/10.31351/vol32issSuppl.pp42-53

[18] Alkhiro A R, Ghareeb M M. Formulation and evaluation of iornoxicam as dissolving microneedle patch. Iraqi J Pharm Sci. 2020; 29(1) 184- 194. https://doi.org/10.31351/vol29iss1pp184-194

[19] Muhammed K and et al. Formulation and characterization of a cream containing extract of fenugreek seeds. Acta Poloniae Pharmaceutica ñ Drug Research. 2010; 67 (2):173- 178.

[20] Abu Tbeekh H T, Mosa H A, Alsunboli M H. Efficacy of Verapamil Combined with Zinc Oxide for Anal Fissure Management. Journal port Science Research. 2024: 7. 10.36371/port.2024.special.42

[21] Neamah A J, Ghareeb M M, Rashid M A. Ionic Liquid: A Green Designer Solvent for Topical Delivery of Nano System. ma'aen journal for medical sciences 2022;1:31e37. https://doi.org/10.55810/2789-9136.1008

[22] Thomas L M, Khasraghi A H. 12Nanotechnology-BasedTopical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview. Iraqi J Pharm Sci. 2020: 29 (1). DOI https://doi.org/10.31351/vol29iss1pp12-32

[23] Kadhum R W and et al. A nanotechnological approach for enhancing the topical drug delivery by newly developed liquid crystal formulations. IJDDT. 2021: 11(3).

[24] Abdullah T M, Al-Kinani K K. Topical propranolol hydrochloride nanoemulsion: a promising approach drug delivery for infantile hemangiomas. Iraqi J Pharm Sci. 2023; 32: 300- 315. https://doi.org/10.31351

[25] Ghareeb M M, Mohammed M S. Topical nanoemulsion-based gel of isoconazole nitrate. Al Mustansiriyah Journal of Pharmaceutical Sciences. 2023; 23 (4): 378.

[26] Abbas M M, Rajab N A. Etodolac topical nanosponges hydrogel preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi J Pharm Sci. 2019; 28(1). DOI: https://doi.org/10.31351/

[27] Alwan L A, Al-Akkam E J. Formulation and evaluation of transdermal dissolved microneedles patches for meloxicam. International Journal of Drug Delivery Technology. 2021;11(3):656-662.

[28] Banerjee D, Kumar M, Mukopadayay S. Formulation and evaluation of herbal body lotion: A review. International Journal of Health Sciences. 2022; 6(S2), 13342–13349. https://doi.org/10.53730/ijhs.v6nS2.8531

[29] Khullar R et al. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal (2012)20,63–67.

[30] Babu D N , Nbdalrazaq NA , Zakifareed Y Y. Simultaneous Estimation Of Aclidinium Bromide And Formoterol Fumarate In Combined Formulation By Rp Hplc Method. Nat. Volatiles & Essent. Oils, 2021; 8(6): 3995-4016.

[31] Dawooda B Yand Kassab H J. preparation and in vitro evaluation of naproxen as a ph sensitive ocular in situ gel. International Journal of Applied Pharmaceutics. 2019; 11: 37- 44

A Review article: Topical Drug Delivery System (Skin). (2024). Journal Port Science Research, 7(issue), 558-563. https://doi.org/10.36371/port.2024.special.44

كيفية الاقتباس

A Review article: Topical Drug Delivery System (Skin). (2024). Journal Port Science Research, 7(issue), 558-563. https://doi.org/10.36371/port.2024.special.44

الأعمال الأكثر قراءة لنفس المؤلف/المؤلفين